STUDYING THE PROPERTIES OF XENOPERICARDIUM IN VIVO,
DIFFERENTLY PROCESSED BY THE CHEMICAL AND FERMENTATIVE METHOD

Kalmin Oleg Vital'evich, Doctor of medical sciences, professor, head of sub-department of human anatomy, Medical institute, Penza State University (Penza, 40 Krasnaya str.), ovkalmin@gmail.com
Nikishin Dmitriy Viktorovich, Candidate of medical sciences, senior lecturer, sub-department of human anatomy, Medical institute, Penza State University (Penza, 40 Krasnaya str.), nikishindv@gmail.com
Venediktov Aleksey Aleksandrovich, General manager, «Kardioplant» Ltd. (Penza, 1 Tsentralnaya str.), venediktovpenza@gmail.com
Zhivaeva Lyubov' Vladimirovna, Postgraduate student, Penza State University (Penza, 40 Krasnaya str.), lyubasha8891@mail.ru
Fuki Valentina Konstantinovna, Candidate of chemical sciences, scientific adviser, «Kardioplant» Ltd. (Penza,1 Tsentralnaya str.), venediktovpenza@gmail.com
Gengin Mikhail Trofimovich, Doctor of biological sciences, professor, head of sub-department of biochemistry, Pedagogical institute named after V. G. Belinsky, Penza State University (Penza, 40 Krasnaya str.), gengin07@yandex.ru

615.461:616.12-089.843

Objective: to study the physical and mechanical properties of xenopericardium treated with standard and modified methods, and to investigate biodegradation of the materials obtained in vivo. Using the tensile machine the authors have studied the physical and mechanical properties of the samples of xenopericardium treated with standard and modified methods. The samples of xenopericardium were implanted into Wistar white rat males. After 2 weeks, 1 and 2 month samples were extracted and underwent histological study of material. It has been found that the modified xenopericardium has a higher modulus and strain at break, a higher withstand load is less deformed at the maximum load in comparison with the material treated by the patented chemoenzymatic method. Histological examination revealed that the biodegradation and biointegration process in samples subject to active standard treatment are already evident by the end of the first month unlike xenopericardium processed by a modified method in which these processes are activated by the end of the second month. The results show the effectiveness of the modified xenopericardium in reconstructive surgeries where there is the need for long-term conservation of the mechanical strength of the graft. The potential fields of application of the obtained material are traumatology, urology and abdominal surgery.

xenopericardium, chemical and fermentative method, biodegradation, physical and mechanical properties.

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